F048 Chronic Urticaria: What's New
DESCRIPTION
The purpose of this session is to highlight the recent major advances in this field as CSU and CIndU cases continue to persist despite being treated with antihistamines, and Omalizumab. New targeted treatments Dupilumab and Remibrutinib have been approved for use in CSU the last year . Furthermore dermatologists will be presented with diagnostic and treatment algorithms based on evidence-based guidelines, and patient specific factors. In addition the dermatologists will be presented with and new drugs in the pipeline that target CSU and CIndU.
LEARNING OBJECTIVES
Recognize Spontaneous CU (CSU) and Inducible CU (CIndU) through identification of the clinical symptoms and associated biomarker testing
Describe evidence-based strategies for treatment selection considering clinical guidelines and patient-specific factors
Review and describe the mechanisms of CSU and emerging biologic therapies and small molecules in the treatment of CSU and CIndU
DIRECTOR
Gil Yosipovitch, MD
SPEAKERS
Ana M. Gimenez-Arnau, MD, IFAAD
Jason Ezra Hawkes, MD, MS, FAAD
Oregon Medical Research Center
Brian S. Kim, MD, FAAD
Icahn School of Medicine at Mount Sinai
Martin Metz, MD
DISCLOSURES
Ana M. Gimenez-Arnau, MD, IFAAD
Almirall – Advisory Board(Fees); Amgen – Advisory Board(Fees); AstraZeneca – Investigator(Grants/Research Funding); Avene – Speaker(Fees); Blueprint Medicines – Advisory Board(Fees); Celldex – Investigator(Grants/Research Funding); celtrium – Advisory Board(Honoraria); Escient – Investigator(Grants/Research Funding); Evommune – Advisory Board(Honoraria); Genentech – Investigator(Grants/Research Funding); Grupo Menarini Centroamerica – Speaker(Fees); GSK – Advisory Board(Fees); Harmonic Bio – Advisory Board(No Compensation Received); Incyte Corporation – Advisory Board(No Compensation Received); Instituto de Salud Carlos III – Investigator(Grants/Research Funding); Jasper Therapeutics – Advisory Board(Fees); Leo Pharma – Investigator(Grants/Research Funding); Mitsubishi Tanabe Pharma Development America – Advisory Board(Fees); Noucor, – Advisory Board(Fees); Novartis Pharmaceuticals Corp. – Advisory Board(Fees), Investigator(Grants/Research Funding); Pfizer – Advisory Board(No Compensation Received); RAPT Therapeutics – Advisory Board(Honoraria); Sanofi–Regeneron – Advisory Board(Fees), Investigator(Grants/Research Funding); Septerna – Advisory Board(Fees); Servier – Advisory Board(Fees);
Jason Ezra Hawkes, MD, MS, FAAD
AbbVie – Advisory Board(Fees), Investigator(Grants/Research Funding); Acelyrin – Investigator(Grants/Research Funding); Allakos – Investigator(Grants/Research Funding); Alumis – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Amgen – Investigator(Grants/Research Funding); Apogee Therapeutics – Consultant (1099 relationship)(No Compensation Received), Investigator(Grants/Research Funding); Arcutis, Inc. – Advisory Board(Fees); Blueprint Medicines – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Investigator(Grants/Research Funding); Celldex – Investigator(Grants/Research Funding); Concert Pharmaceuticals – Investigator(Grants/Research Funding); Eli Lilly and Company – Advisory Board(Fees), Investigator(Grants/Research Funding), Speaker(Honoraria); Galderma – Consultant (1099 relationship)(Fees), Speaker(Honoraria); Incyte – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Kymera Therapeutics – Investigator(Grants/Research Funding); LEO Laboratories Ltd (LEO Pharma) – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding), Speaker(Fees), Speaker(Honoraria); Novartis – Advisory Board(Fees), Consultant (1099 relationship)(Fees), Speaker/Faculty Education(Honoraria); Organon – Advisory Board(Honoraria), Speaker(Honoraria); Oruka Therapeutics – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Priovant Therapeutics – Investigator(Grants/Research Funding); Regeneron Pharmaceuticals, Inc. – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees), Speaker(Honoraria), Stockholder(Stock); Sanofi Genzyme – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding), Speaker(Honoraria); Sun Pharmaceutical Industries Ltd. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); UCB – Advisory Board(Honoraria), Consultant(Fees), Speaker(Honoraria);
Brian S. Kim, MD, FAAD
AbbVie – Consultant(Fees); Almirall – Advisory Board(Honoraria); Alys Pharmaceuticals – Stockholder Private Company(Stock); AstraZeneca – Consultant (1099 relationship)(Fees); Eli Lilly and Company – Advisory Board(Honoraria); Evommune, Inc. – Consultant (1099 relationship)(Fees); Galderma – Consultant (1099 relationship)(Fees); Guidepoint Global, LLC – Consultant(Fees); Leo Pharma Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Locus Biosciences – Stockholder(Stock); Novartis – Advisory Board(Honoraria); Pfizer Inc. – Consultant(Honoraria); Recens Medical – Consultant(Fees); Regeneron – Consultant (1099 relationship)(Honoraria); Sanofi – Consultant(Fees); Septerna – Consultant (1099 relationship)(Fees);
Martin Metz, MD
AbbVie – Speaker(Honoraria); Allakos – Investigator(No Compensation Received); Allegria Therapeutics – Advisory Board(Honoraria); Almirall – Speaker(Honoraria), Speaker/Faculty Education(Honoraria); Amgen – Advisory Board(Honoraria); Arcutis Biotherapeutics – Advisory Board(Honoraria); argenx – Advisory Board(Honoraria), Consultant (1099 relationship)(Honoraria); AstraZeneca – Advisory Board(Honoraria); Astria Therapeutics – Advisory Board(Honoraria); Attovia Therapeutics – Consultant (1099 relationship)(Honoraria); Bayer – Consultant (1099 relationship)(Honoraria); Berlin Chemie – Speaker(Honoraria); Blueprint Medicines – Advisory Board(Honoraria); candid – Consultant (1099 relationship)(Honoraria); Celldex – Advisory Board(Honoraria); Celltrion – Speaker(Honoraria); Deep Apple Therapeutics – Advisory Board(Honoraria); Eli Lilly – Advisory Board(Honoraria); Enanta Pharmaceuticals – Consultant (1099 relationship)(Honoraria); Escient Pharmaceuticals, Inc – Advisory Board(Honoraria); Evommune, Inc. – Advisory Board(Honoraria); Excellergy – Consultant (1099 relationship)(Honoraria); FatiAbGen – Consultant (1099 relationship)(Honoraria); Galderma – Advisory Board(Honoraria), Speaker(Honoraria); Generate Biomedicines – Consultant (1099 relationship)(Honoraria); GlaxoSmithKline Immunology – Advisory Board(Honoraria); Granular Therapeutics – Advisory Board(Honoraria); Incyte Corporation – Advisory Board(Honoraria); InflaRx – Consultant (1099 relationship)(Honoraria); Japan Tobacco Inc. – Consultant (1099 relationship)(Honoraria); Jasper Therapeutics – Advisory Board(Honoraria); Johnson & Johnson Pharmaceutical Research & Development – Advisory Board(Honoraria); Lycia Therapeutics – Consultant (1099 relationship)(Honoraria); Novartis – Advisory Board(Honoraria), Speaker(Honoraria); Ono – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Speaker(Honoraria); RAPT Therapeutics – Advisory Board(Honoraria); Regeneron Pharmaceuticals, Inc. – Advisory Board(Honoraria); Sanofi – Advisory Board(Honoraria), Speaker(Honoraria); Santa Ana Bio – Advisory Board(Honoraria); Septerna – Advisory Board(Honoraria); Tupos – Consultant (1099 relationship)(Honoraria);
Gil Yosipovitch, MD
AbbVie – Advisory Board(Honoraria); Arcutis, Inc. – Advisory Board(Honoraria); Cara Therapeutics – Advisory Board(Honoraria); CeraVe – Advisory Board(Honoraria); Eli Lilly – Investigator(Fees), Investigator(Grants/Research Funding); Eli Lilly and Company – Advisory Board(Honoraria); escient – Investigator(Fees), Investigator(Grants/Research Funding); Galderma – Advisory Board(Honoraria); Galderma Laboratories, L.P. – Consultant(Honoraria), Investigator(Fees), Investigator(Grants/Research Funding); GSK – Advisory Board(Honoraria); Kamari Pharma – Consultant(Fees); Kiniksa Pharmaceuticals, Ltd. – Investigator(Grants/Research Funding); Maruho Co., Ltd – Speaker/Faculty Education(Fees); Novartis – Consultant(Honoraria), Investigator(Fees), Investigator(Grants/Research Funding); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Pierre Fabre – Consultant(Honoraria); Sanofi/Regeneron – Advisory Board(Honoraria), Investigator(Fees), Investigator(Grants/Research Funding); Vifor Pharma – Consultant(Fees);