F021 Where Do We Stand? The Pathogenesis and Treatment of Melasma
DESCRIPTION
Melasma is a global disorder of major cosmetic significance. It negatively impacts the quality of life of patients. The pathogenesis of melasma is complex. Multiple recent studies document the interplay of genetics, inflammation, oxidative stress, abnormal vascular responses, senescent fibroblasts, and sensitivity to hormones in the pathogenesis of the disorder. Recent data suggest that it is a phenotype of photodamage. Multiple new therapies offer significant improvement. This forum will review the most recent global advances in pathogenesis and treatment of melasma. Therapies reviewed will include photoprotection, topical and oral agents, chemical peels, microneedling, PRP, lasers and emerging therapies.
LEARNING OBJECTIVES
Succinctly review new data on pathogenesis of melasma.
Discuss conventional therapies including hydroquinone, & non-hydroquinone lightening agents, as well as new targets & new agents for skin lightening.
Review resurfacing procedures, including chemical peels, lasers & energy based devices, PRP, & microneedling. We will review the risk/benefit ratios of each procedure.
SCHEDULE
1:00 PM
Introduction
Pearl E. Grimes, MD, FAAD
1:05 PM
The Tempest: Understanding Melasma
Pearl E. Grimes, MD, FAAD
1:20 PM
The Science of Photoprotection
Maria Ivonne Arellano-Mendoza, MD, IFAAD
1:35 PM
Conventional Topical Therapies
Nada Elbuluk, MD, FAAD
1:47 PM
Emerging Therapies: The South American Experience
Helio A. Miot, MD, PhD, IFAAD
2:02 PM
Systemic Therapies
Seemal R. Desai, MD, FAAD
2:14 PM
Chemical Peeling, Microneedling & PRP, Best Practices
Seaver Soon, MD, FAAD
2:29 PM
Laser & Energy Based Devices
E. Victor Ross Jr., MD, FAAD
2:44 PM
Q&A
DIRECTOR
Pearl E. Grimes, MD, FAAD
Vitiligo & Pigmentation Institute of Southern California
SPEAKERS
Maria Ivonne Arellano-Mendoza, MD, IFAAD
Seemal R. Desai, MD, FAAD
Nada Elbuluk, MD, FAAD
University of Southern California
Helio A. Miot, MD, PhD, IFAAD
Faculdade de Medicina de Botucatu - Unesp
E. Victor Ross Jr., MD, FAAD
Seaver Soon, MD, FAAD
DISCLOSURES
Maria Ivonne Arellano-Mendoza, MD, IFAAD
Bioderma – Speaker(Honoraria); Cantabria Labs – Speaker(Honoraria); Farmapiel – Speaker(Honoraria); Galderma Laboratories, LP – Advisory Board(Honoraria); Genove Dermatologics – Speaker(Honoraria); ISDIN – Advisory Board(Honoraria); ISIS Pharma – Speaker(Honoraria); NENUPHARM – Investigator(Honoraria); Pierre Fabre Dermo Cosmetique France – Advisory Board(Honoraria); Sanfer, S.L. – Speaker(Honoraria);
Seemal R. Desai, MD, FAAD
AbbVie – Consultant(Fees), Speaker(Fees); Apogee Therapeutics – Consultant(Fees); Arcutis, Inc. – Consultant (1099 relationship)(Honoraria), Speaker(Honoraria); Beiersdorf, Inc. – Consultant(Fees); Bristol-Myers Squibb – Consultant(Fees); Castle Biosciences – Consultant(Fees); Eli Lilly and Company – Consultant(Fees); Ferndale Laboratories, Inc. – Consultant(Honoraria); Foundation for Research & Education of Dermatology – Advisory Board(Fees); Galderma Laboratories, LP – Consultant(Fees), Speaker(Honoraria); Global Vitiligo Foundation – Board of Directors(No Compensation Received); Gore Range Capital – Consultant(Stock Options), Stockholder(Stock Options); Illuminate Skin Care LLC – Founder(Other Financial Benefit); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); International Society of Dermatology – Board of Directors(No Compensation Received); Janssen Pharmaceuticals, Inc – Consultant(Fees); Johnson and Johnson – Consultant(Fees); L'Oreal USA Inc. – Consultant(Fees); Leo Pharma Inc. – Consultant(Fees); Lyceum Health – Consultant(Fees); Medscape – Other(Fees); National Psoriasis Foundation – Other(No Compensation Received); Ortho Dermatologics – Consultant(Fees); PDH Holdings LLC – Other(No Compensation Received); Pfizer Inc. – Consultant(Fees), Speaker(Honoraria); Sanofi/Regeneron – Consultant(Fees); Scientis – Consultant(Fees); Sensus Healthcare – Consultant (1099 relationship)(Honoraria); Skin Science Advisors – Consultant(Fees); SkinMedica, Inc. – Investigator(Grants/Research Funding); UCB – Consultant(Fees); VYNE Therapeutics – Consultant(Fees);
Nada Elbuluk, MD, FAAD
AbbVie – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Beiersdorf – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Canfield Scientific, Inc. – Consultant (1099 relationship)(Fees); Dior – Advisory Board(Fees); Eli Lilly and Company – Advisory Board(Fees), Investigator(Grants/Research Funding); Global Vitiligo Foundation – Board of Directors(No Compensation Received); Incyte Corporation – Advisory Board(Fees), Consultant(Fees); Janssen Biotech – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Kao USA – Consultant (1099 relationship)(Fees); Kenvue – Advisory Board(Fees); L'Oreal USA Inc. – Advisory Board(Fees); McGraw-Hill Companies – Advisory Board(Fees), Other(Other Financial Benefit); Pfizer Inc. – Advisory Board(Fees), Investigator(Grants/Research Funding); Sanofi – Advisory Board(Fees); SkinCeauticals LLC – Consultant (1099 relationship)(Fees); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); Teva Pharmaceuticals USA – Consultant (1099 relationship)(Fees); The Skin of Color Society – Board of Directors(No Compensation Received); VeraDermics Inc. – Consultant (1099 relationship)(Fees); VisualDx – Consultant(Stock Options); Women's Dermatologic Society – Board of Directors(No Compensation Received);
Pearl E. Grimes, MD, FAAD
AbbVie – Consultant(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); L'Oreal USA Inc. – Consultant(Grants/Research Funding); Laseroptek USA – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Investigator(Grants/Research Funding); Procter & Gamble Company – Consultant(Honoraria); Scientis – Consultant (1099 relationship)(Honoraria); SkinBetter Science – Investigator(Grants/Research Funding); Versicolor Technologies – Consultant (1099 relationship)(Honoraria), Stockholder Private Company(Honoraria);
Helio A. Miot, MD, PhD, IFAAD
AbbVie – Investigator(Fees); Beiersdorf, Inc. – Speaker(Fees); Galderma Brasil Ltda – Consultant (1099 relationship)(Fees); Johnson & Johnson Pharmaceutical Research & Development – Consultant (1099 relationship)(Fees); L'Oreal – Consultant (1099 relationship)(Fees); Lecieza – Consultant (1099 relationship)(Fees); Merz Aesthetics – Other(Fees); Pfizer Inc. – Speaker/Faculty Education(Fees); Pierre Fabre Dermatologie – Investigator(Fees); Sanofi Genzyme – Speaker(Fees); TheraSkin Farmacêutica – Investigator(Fees);
E. Victor Ross Jr., MD, FAAD
Acclaro Medical – Investigator(Grants/Research Funding); Benev – Consultant(Honoraria); Cutera, Inc. – Investigator(Equipment); laser optek – Other(Honoraria); laseroptek – Other(Honoraria); Lumenis – Investigator(Equipment), Investigator(Honoraria); Lutronic – Consultant(Honoraria); Venus Concept – Investigator(Grants/Research Funding);
Seaver Soon, MD, FAAD
Beiersdorf, Inc. – Advisory Board(Honoraria); Caliway Biopharmaceuticals Co., Ltd – Advisory Board(Honoraria); CP Skin Health – Speaker(Honoraria); Parallel Health – Advisory Board(Stock Options); VeraDermics Inc. – Advisory Board(Honoraria);