S025 JAK Inhibitors: A New Frontier in Dermatology
DESCRIPTION
Janus kinase (JAK) inhibitors are a new class of medicine in dermatology and are increasingly important due to their unmatched therapeutic potential across inflammatory skin diseases. The application of JAK inhibitors to dermatologic diseases will be presented, including the results of clinical trials and case series. The safety profile of JAK inhibitors will be discussed in detail. The audience for this session will be dermatologists who care for patients with alopecia areata, atopic dermatitis and prurigo nodularis and pruritus, granuloma annulare and sarcoidosis, lichen planus, lichen planopilaris, lupus and dermatomyositis and other CTD, hidradenitis suppurativa, and vitiligo.
LEARNING OBJECTIVES
Describe a new and important class of medications in dermatology.
Utilize JAK inhibitors for the treatment of alopecia areata, atopic dermatitis, dermatomyositis, granuloma annulare and sarcoidosis, hidradenitis suppurativa, lichen planus, lupus, pruritus, and vitiligo.
Summarize the safety profile of JAK inhibitors and differentiate the safety profile among disease states.
SCHEDULE
9:00 AM
Why JAK Inhibitors are so Broadly Effective
Brett King, MD, PhD, FAAD
9:10 AM
JAK Inhibitors for Vitiligo
George Han, MD, PhD, FAAD
9:25 AM
JAK Inhibitors for Dermatomyositis, Lupus, and SAVI
Ruth Ann Vleugels, MD, MBA, MPH, FAAD
9:40 AM
Q&A
George Han, MD, PhD, FAAD, Ruth Ann Vleugels, MD, MBA, MPH, FAAD
9:50 AM
JAK Inhibitors for Sarcoidosis and Granuloma Annulare
Avrom Caplan, MD, FAAD
10:05 AM
Hidradenitis Suppurativa and Pyoderma Gangrenosum
Martina J. Porter, MD, FAAD
10:20 AM
Q&A
Avrom Caplan, MD, FAAD, Martina J. Porter, MD, FAAD
10:30 AM
JAK Inhibitors for Lichen Planus and Lichen Planopilaris
Tiffany Mayo, MD, FAAD
10:45 AM
JAK Inhibitors for Alopecia Areata
11:00 AM
Q&A
Tiffany Mayo, MD, FAAD
11:10 AM
JAK Inhibitors for Atopic Dermatitis, Prurigo Nodularis, and Pruritus
Eric Lawrence Simpson, MD, FAAD
11:30 AM
Understanding the Safety Profile of JAK Inhibitors
Brett King, MD, PhD, FAAD
11:50 AM
Q&A
Brett King, MD, PhD, FAAD, Eric Lawrence Simpson, MD, FAAD
DIRECTOR
Brett King, MD, PhD, FAAD
SPEAKERS
Avrom Caplan, MD, FAAD
George Han, MD, PhD, FAAD
Tiffany Mayo, MD, FAAD
Martina J. Porter, MD, FAAD
Beth Israel Deaconess Medical Center & Harvard Medical School
Eric Lawrence Simpson, MD, FAAD
Ruth Ann Vleugels, MD, MBA, MPH, FAAD
Mass General Brigham
DISCLOSURES
Avrom Caplan, MD, FAAD
Novartis – Consultant (1099 relationship)(Fees); Priovant Therapeutics – Advisory Board(Fees), Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding);
George Han, MD, PhD, FAAD
AbbVie – Speaker(Honoraria); Amgen – Advisory Board(Honoraria); Avillion – Investigator(Grants/Research Funding); Boehringer Ingelheim – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Advisory Board(Honoraria); Castle Biosciences – Advisory Board(Honoraria); Celgene – Investigator(Grants/Research Funding); DermTech Inc. – Advisory Board(Honoraria); Eli Lilly and Company – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Hikma Pharmaceuticals – Speaker/Faculty Education(Honoraria); Incyte Corporation – Advisory Board(Honoraria), Speaker(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); LearnHealth/LearnSkin – Speaker/Faculty Education(Honoraria); MC2 Therapeutics – Investigator(Grants/Research Funding); Novartis Pharmaceuticals Corp. – Investigator(Grants/Research Funding); Othro Dermatologics – Advisory Board(Honoraria); Pfizer Inc. – Speaker(Honoraria); Regeneron Pharmaceuticals, Inc. – Advisory Board(Honoraria), Speaker(Honoraria); Sanofi – Advisory Board(Honoraria); Sanofi Genzyme – Speaker(Honoraria); Sonoma Pharmaceuticals – Advisory Board(Honoraria); Sun Pharmaceutical Industries Ltd. – Speaker(Honoraria); UCB – Advisory Board(Honoraria);
Brett King, MD, PhD, FAAD
AbbVie – Advisory Board(Honoraria), Speaker(Honoraria); Amgen – Consultant (1099 relationship)(Fees); Apogee Therapeutics – Consultant (1099 relationship)(Fees); Aquestive Therapeutics – Consultant (1099 relationship)(Fees); BiologicsMD, Inc. – Consultant(Stock Options); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Eli Lilly and Company – Consultant(Fees), Investigator(Fees), Speaker(Honoraria); Galderma – Advisory Board(Honoraria); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Fees); Incyte Corporation – Advisory Board(Honoraria), Consultant(Fees), Data Safety Monitoring Board(Fees); Leo Pharma – Advisory Board(Honoraria); Pfizer Inc. – Advisory Board(Fees), Advisory Board(Honoraria), Consultant(Fees), Investigator(Fees), Speaker(Honoraria); Q32 Bio Inc. – Consultant (1099 relationship)(Fees); Regeneron – Advisory Board(Honoraria), Speaker(Honoraria); Sanofi – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); Sanofi Genzyme – Speaker(Honoraria); Soterios Pharma – Consultant (1099 relationship)(Fees); Sun Pharmaceutical Industries Ltd. – Consultant(Fees), Investigator(Fees); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); TWi Biotechnology, Inc. – Consultant(Fees);
Tiffany Mayo, MD, FAAD
AbbVie – Consultant (1099 relationship)(Honoraria); Acelyrin – Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Advisory Board(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria), Investigator(Grants/Research Funding); ChemoCentryx – Investigator(Grants/Research Funding); Eli Lilly and Company – Investigator(Grants/Research Funding); Galderma – Investigator(Grants/Research Funding); Incyte – Investigator(Grants/Research Funding); ITB-MED – Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Leo Pharma – Advisory Board(Honoraria); Merck – Advisory Board(Honoraria); Novartis – Advisory Board(Honoraria); Oruka Therapeutics – Advisory Board(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Procter & Gamble Company – Investigator(Grants/Research Funding); Sanofi – Advisory Board(Honoraria); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); UCB – Advisory Board(Honoraria);
Martina J. Porter, MD, FAAD
AbbVie – Consultant (1099 relationship)(No Compensation Received), Investigator(Grants/Research Funding); Alumis – Consultant(Fees); AnaptysBio – Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Bayer – Investigator(Grants/Research Funding); Beth Israel Deaconess Medical Center – Other(Patent royalties or other compensation for Intellectual Property Rights); Bristol-Myers Squibb – Investigator(Grants/Research Funding); Eli Lilly – Consultant (1099 relationship)(No Compensation Received); Eli Lilly and Company – Investigator(Grants/Research Funding); FIDE – Consultant (1099 relationship)(Fees); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Investigator(Grants/Research Funding); Janssen Research & Development, LLC – Consultant(Fees); Merck – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Mirador – Investigator(Grants/Research Funding); Moonlake – Investigator(Grants/Research Funding); MoonLake Immunotherapeutics – Consultant (1099 relationship)(Fees); Navigator Medicines – Consultant (1099 relationship)(Fees); Novartis – Consultant(Fees), Investigator(Grants/Research Funding); Oasis Pharmaceuticals – Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Prometheus Laboratories, Inc. – Consultant (1099 relationship)(No Compensation Received), Investigator(Grants/Research Funding); Regeneron – Investigator(Grants/Research Funding); Sanofi – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Sonoma Biotherapeutics – Consultant (1099 relationship)(No Compensation Received), Investigator(Grants/Research Funding); Trifecta Clinical – Consultant(Fees); UCB – Consultant(Fees), Investigator(Grants/Research Funding); Zura Bio – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding);
Eric Lawrence Simpson, MD, FAAD
AbbVie – Consultant(Fees), Investigator(Grants/Research Funding); Aclaris Therapeutics Inc. – Consultant (1099 relationship)(Fees); Acrotech Biopharma Inc – Investigator(Grants/Research Funding); Amgen – Consultant(Fees), Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Consultant(Fees); Arcutis, Inc. – Investigator(Grants/Research Funding); ASLAN – Investigator(Grants/Research Funding); Astria Therapeutics – Consultant (1099 relationship)(Fees); Attovia Therapeutics, Inc – Consultant (1099 relationship)(Fees); Bambusa Therapeutics Inc – Consultant (1099 relationship)(Fees); Castle Biosciences – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); CorEvitas – Consultant(Fees), Investigator(Grants/Research Funding); Demira – Consultant(Fees); Dermavant – Investigator(Grants/Research Funding); Dermira – Investigator(Grants/Research Funding); Eli Lilly and Company – Consultant(Fees), Investigator(Grants/Research Funding); Evomunne – Consultant (1099 relationship)(Fees); FIDE – Speaker/Faculty Education(Fees); Genentech, Inc. – Consultant (1099 relationship)(Fees); Impetus Healthcare – Consultant (1099 relationship)(Fees); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); Inmagene Biopharmaceuticals – Consultant (1099 relationship)(Fees); Innovaderm Research Inc. – Consultant (1099 relationship)(Fees); Janssen Pharmaceuticals, Inc – Consultant (1099 relationship)(Fees); Kymera Therapeutics – Consultant (1099 relationship)(Fees); La Fonderie Ressources – Consultant (1099 relationship)(Fees); Leo Pharma Inc. – Consultant(Fees); National Jewish Health – Investigator(Grants/Research Funding); NUMAB Therapeutics AG – Consultant (1099 relationship)(Fees); Pfizer Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Recludix Pharma – Consultant (1099 relationship)(Fees); Regeneron – Consultant(Fees), Investigator(Grants/Research Funding); Roche Products Ltd – Consultant (1099 relationship)(Fees); Sanofi – Investigator(Grants/Research Funding); Sanofi Genzyme – Consultant(Fees), Investigator(Grants/Research Funding); SITRYX – Consultant (1099 relationship)(Fees); Target RWE – Investigator(Grants/Research Funding); Veriskin – Investigator(Grants/Research Funding);
Ruth Ann Vleugels, MD, MBA, MPH, FAAD
AbbVie – Consultant (1099 relationship)(Honoraria); Apogee Therapeutics – Consultant (1099 relationship)(Honoraria); Astra Zeneca – Consultant (1099 relationship)(Honoraria); BMS – Consultant (1099 relationship)(Honoraria); Eli Lilly – Consultant (1099 relationship)(Honoraria); Priovant Therapeutics – Consultant (1099 relationship)(Honoraria);