F035 Where do We Stand? The Pathogenesis and Treatment of Melasma
DESCRIPTION
Melasma is a global disorder of major cosmetic significance. It negatively impacts the quality of life of patients. The pathogenesis of melasma is complex. Multiple recent studies document the interplay of genetics, inflammation, oxidative stress, abnormal vascular responses, senescent fibroblasts, and sensitivity to hormones in the pathogenesis of the disorder. Recent data suggest that it is a phenotype of photodamage. Multiple new therapies offer significant improvement. This forum will review the most recent global advances in pathogenesis and treatment of melasma. Therapies reviewed will include photoprotection, topical and oral agents, chemical peels, microneedling, PRP, lasers, light sources and emerging therapies.
LEARNING OBJECTIVES
Succinctly summarize new data on the epidemiology and pathogenesis of melasma.
Review new data regarding photo protection strategies and treatment options including topical and oral agents, and resurfacing modalities.
Discuss case-based algorithms and best practices for managing patients with this therapeutically challenging condition.
SCHEDULE
1:00 PM
Introduction
Pearl E. Grimes, MD, FAAD
1:05 PM
The Epidemiology and Pathogenesis of Melasma: The Winding Road of Discovery
Pearl E. Grimes, MD, FAAD
1:20 PM
The New Science of Photoprotection
Thierry Passeron, MD, PhD
1:35 PM
The Landscape of Topical Therapies
Nada Elbuluk, MD, FAAD
1:47 PM
Topical Therapies: New Paradigms
Heather Clare Woolery-Lloyd, MD, FAAD
2:00 PM
Oral Therapies for Melasma
Seemal R. Desai, MD, FAAD
2:15 PM
Chemical Peeling, Microneedling, and PRP Best Practices
Rashmi Sarkar, MD, IFAAD
2:30 PM
Lasers and Energy Based Devices
Arielle N.B. Kauvar, MD, FAAD
2:45 PM
Q&A
DIRECTOR
Pearl E. Grimes, MD, FAAD
SPEAKERS
Seemal R. Desai, MD, FAAD
Nada Elbuluk, MD, FAAD
Arielle N.B. Kauvar, MD, FAAD
Thierry Passeron, MD, PhD
Rashmi Sarkar, MD, IFAAD
Heather Clare Woolery-Lloyd, MD, FAAD
HANDOUTS
DISCLOSURES
Seemal R. Desai, MD, FAAD
AbbVie – Consultant(Fees), Speaker(Fees); Apogee Therapeutics – Consultant(Fees); Arcutis, Inc. – Consultant (1099 relationship)(Honoraria), Speaker(Honoraria); Beiersdorf, Inc. – Consultant(Fees); Bristol-Myers Squibb – Consultant(Fees); Castle Biosciences – Consultant(Fees); Eli Lilly and Company – Consultant(Fees); Ferndale Laboratories, Inc. – Consultant(Honoraria); Foundation for Research & Education of Dermatology – Advisory Board(Fees); Galderma Laboratories, LP – Consultant(Fees), Speaker(Honoraria); Global Vitiligo Foundation – Board of Directors(No Compensation Received); Gore Range Capital – Consultant(Stock Options), Stockholder(Stock Options); Illuminate Skin Care LLC – Founder(Other Financial Benefit); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); International Society of Dermatology – Board of Directors(No Compensation Received); Janssen Pharmaceuticals, Inc – Consultant(Fees); Johnson and Johnson – Consultant(Fees); L'Oreal USA Inc. – Consultant(Fees); Leo Pharma Inc. – Consultant(Fees); Lyceum Health – Consultant(Fees); Medscape – Other(Fees); National Psoriasis Foundation – Other(No Compensation Received); Ortho Dermatologics – Consultant(Fees); PDH Holdings LLC – Other(No Compensation Received); Pfizer Inc. – Consultant(Fees), Speaker(Honoraria); Sanofi/Regeneron – Consultant(Fees); Scientis – Consultant(Fees); Sensus Healthcare – Consultant (1099 relationship)(Honoraria); Skin Science Advisors – Consultant(Fees); SkinMedica, Inc. – Investigator(Grants/Research Funding); UCB – Consultant(Fees); VYNE Therapeutics – Consultant(Fees);
Nada Elbuluk, MD, FAAD
AbbVie – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Arcutis, Inc. – Consultant (1099 relationship)(Fees); Beiersdorf, Inc. – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Canfield Scientific, Inc. – Consultant (1099 relationship)(Fees); Dior – Advisory Board(Fees); Eli Lilly and Company – Advisory Board(Fees), Investigator(Grants/Research Funding); Global Vitiligo Foundation – Board of Directors(No Compensation Received); Incyte Corporation – Advisory Board(Fees), Consultant(Fees); Janssen Biotech – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Kao USA – Consultant (1099 relationship)(Fees); Kenvue – Advisory Board(Fees); L'Oreal USA Inc. – Advisory Board(Fees); McGraw-Hill Companies – Advisory Board(Fees), Other(Other Financial Benefit); Pfizer Inc. – Advisory Board(Fees), Investigator(Grants/Research Funding); Sanofi – Advisory Board(Fees); SkinCeuticals LLC – Consultant (1099 relationship)(Fees); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); Teva Pharmaceuticals USA – Consultant (1099 relationship)(Fees); The Skin of Color Society – Board of Directors(No Compensation Received); VeraDermics Inc. – Consultant (1099 relationship)(Fees); VisualDx – Consultant(Stock Options);
Pearl E. Grimes, MD, FAAD
AbbVie – Consultant(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); L'Oreal USA Inc. – Consultant(Grants/Research Funding); Laseroptek USA – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Investigator(Grants/Research Funding); Procter & Gamble Company – Consultant(Honoraria); Scientis – Consultant (1099 relationship)(Honoraria); SkinBetter Science – Investigator(Grants/Research Funding); Versicolor Technologies – Consultant (1099 relationship)(Honoraria), Stockholder Private Company(Honoraria);
Arielle N.B. Kauvar, MD, FAAD
Candela Corporation – Investigator(Grants/Research Funding); Lumenis – Investigator(Grants/Research Funding); Sofwave – Investigator(Grants/Research Funding);
Thierry Passeron, MD, PhD
AbbVie – Advisory Board(Honoraria), Speaker/Faculty Education(Honoraria); Almirall – Advisory Board(Honoraria); Amgen – Consultant(Honoraria); Astellas Pharma US, Inc – Investigator(Grants/Research Funding); Beiersdorf, Inc. – Speaker(Honoraria); Bioderma – Speaker/Faculty Education(Honoraria); Celgene Corporation – Investigator(Grants/Research Funding); Cutera, Inc. – Advisory Board(Honoraria); Galderma Research & Development, LLC – Advisory Board(Honoraria); GlaxoSmithKline – Speaker/Faculty Education(Honoraria); Hyphens Pharma – Speaker/Faculty Education(Honoraria); Incyte Corporation – Investigator(Fees), Speaker/Faculty Education(Honoraria); ISDIN – Advisory Board(Honoraria), Speaker(Honoraria); Janssen-Cilag – Advisory Board(Honoraria), Speaker/Faculty Education(Honoraria); Journal of the European Academy of Dermatology and Venereology – Other(No Compensation Received); L'Oréal Research and Innovation – Speaker/Faculty Education(Honoraria); La Roche-Posay Laboratorie Pharmaceutique – Speaker/Faculty Education(Honoraria); Leo Pharma Inc. – Speaker/Faculty Education(Honoraria); Lilly ICOS LLC – Speaker/Faculty Education(Honoraria); Mesoestetic USA Laboratories – Advisory Board(Honoraria); MSD – Advisory Board(Honoraria); Novartis – Advisory Board(Honoraria), Speaker(Honoraria); Pfizer Inc. – Advisory Board(Honoraria); Sanofi – Advisory Board(Honoraria); Sun Pharmaceutical Industries Ltd. – Speaker/Faculty Education(Honoraria); Symrise – Advisory Board(Honoraria); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); Vichy Laboratoires – Advisory Board(Honoraria), Speaker(Honoraria); VYNE Therapeutics – Advisory Board(Honoraria);
Rashmi Sarkar, MD, IFAAD
No financial relationships exist with ineligible companies.
Heather Clare Woolery-Lloyd, MD, FAAD
AbbVie – Consultant (1099 relationship)(Honoraria), Investigator(Other Financial Benefit); Allergan, Inc. – Investigator(Other Financial Benefit); Arcutis Biotherapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Avita – Investigator(Grants/Research Funding); Beiersdorf – Speaker(Fees); Eirion Therapeutics – Investigator(Other Financial Benefit); Eli Lilly and Company – Speaker(Honoraria); Estee Lauder – Speaker(Honoraria); Galderma – Consultant (1099 relationship)(Honoraria), Speaker(Honoraria); Galderma Laboratories, L.P. – Investigator(Other Financial Benefit); Incyte – Speaker(Honoraria); Incyte Corporation – Advisory Board(Honoraria), Consultant (1099 relationship)(Honoraria); Johnson & Johnson Consumer Products Company – Consultant (1099 relationship)(Honoraria); Kenvue – Consultant (1099 relationship)(Honoraria), Speaker(Honoraria); Kymera Therapeutics – Investigator(Grants/Research Funding); L'Oreal USA Inc. – Consultant (1099 relationship)(Honoraria), Speaker(Honoraria); Nutrafol – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Ortho Dermatologics – Advisory Board(Honoraria), Speaker(Honoraria); Pfizer Inc. – Investigator(Other Financial Benefit); Regeneron Pharmaceuticals Inc – Investigator(Grants/Research Funding); TEOXANE Laboratories – Investigator(Grants/Research Funding); Unilever – Consultant (1099 relationship)(Honoraria);