F117 Where do We Stand? The Pathogenesis and Treatment of Melasma
DESCRIPTION
Melasma is indeed a global disorder of major cosmetic significance. It negatively impacts the quality of life of patients. The pathogenesis of melasma is indeed complex. Multiple recent studies document the interplay of genetics, inflammation, oxidative stress, abnormal vascular responses, and sensitivity to hormones in the pathogenesis of the disorder. Recent data suggest that it is a phenotype of photodamage. While there are no cures, multiple new therapies offer significant improvement. This forum will review the most recent global advances in pathogenesis and treatment of melasma. Therapies to be reviewed include sunscreens, topical agents, and oral agents including tranexamic acid, chemical peels, microneedling, PRP, lasers, light sources and emerging therapies.
LEARNING OBJECTIVES
Succinctly review new data on the pathogenesis of melasma.
Review photo protection strategies and treatment options including the spectrum of topical and oral agents for melasma.
Review resurfacing modalities, including the risk/benefit ratio of each procedure.
SCHEDULE
3:30 PM
INTRO
3:35 PM
Pathogenesis of Melasma
Pearl E. Grimes, MD, FAAD
3:55 PM
Photoprotection Strategies
4:10 PM
Topical Therapies
Nada Elbuluk, MD, FAAD
4:30 PM
Oral Therapies
Seemal R. Desai, MD, FAAD
4:45 PM
Chemical Peeling - What's old and new?
Carlos G Wambier, MD, IFAAD
5:00 PM
Lasers & Energy-Based Devices
Omar Ibrahimi, MD, PhD, FAAD
5:15 PM
Q&A
DIRECTOR
Pearl E. Grimes, MD, FAAD
SPEAKERS
Seemal R. Desai, MD, FAAD
Nada Elbuluk, MD, FAAD
Omar Ibrahimi, MD, PhD, FAAD
Carlos G Wambier, MD, IFAAD
HANDOUTS
DISCLOSURES
Seemal R. Desai, MD, FAAD
AbbVie – Consultant(Fees), Speaker(Fees); Apogee Therapeutics – Consultant(Fees); Arcutis, Inc. – Consultant (1099 relationship)(Honoraria), Speaker(Honoraria); Beiersdorf, Inc. – Consultant(Fees); Bristol-Myers Squibb – Consultant(Fees); Castle Biosciences – Consultant(Fees); Eli Lilly and Company – Consultant(Fees); Ferndale Laboratories, Inc. – Consultant(Honoraria); Foundation for Research & Education of Dermatology – Advisory Board(Fees); Galderma Laboratories, LP – Consultant(Fees), Speaker(Honoraria); Global Vitiligo Foundation – Board of Directors(No Compensation Received); Gore Range Capital – Consultant(Stock Options), Stockholder(Stock Options); Illuminate Skin Care LLC – Founder(Other Financial Benefit); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); International Society of Dermatology – Board of Directors(No Compensation Received); Janssen Pharmaceuticals, Inc – Consultant(Fees); Johnson and Johnson – Consultant(Fees); L'Oreal USA Inc. – Consultant(Fees); Leo Pharma Inc. – Consultant(Fees); Lyceum Health – Consultant(Fees); Medscape – Other(Fees); National Psoriasis Foundation – Other(No Compensation Received); Ortho Dermatologics – Consultant(Fees); PDH Holdings LLC – Other(No Compensation Received); Pfizer Inc. – Consultant(Fees), Speaker(Honoraria); Sanofi/Regeneron – Consultant(Fees); Scientis – Consultant(Fees); Sensus Healthcare – Consultant (1099 relationship)(Honoraria); Skin Science Advisors – Consultant(Fees); SkinMedica, Inc. – Investigator(Grants/Research Funding); UCB – Consultant(Fees); VYNE Therapeutics – Consultant(Fees);
Nada Elbuluk, MD, FAAD
AbbVie – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Arcutis, Inc. – Consultant (1099 relationship)(Fees); Beiersdorf, Inc. – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Canfield Scientific, Inc. – Consultant (1099 relationship)(Fees); Dior – Advisory Board(Fees); Eli Lilly and Company – Advisory Board(Fees), Investigator(Grants/Research Funding); Global Vitiligo Foundation – Board of Directors(No Compensation Received); Incyte Corporation – Advisory Board(Fees), Consultant(Fees); Janssen Biotech – Advisory Board(Fees), Consultant (1099 relationship)(Fees); Kao USA – Consultant (1099 relationship)(Fees); Kenvue – Advisory Board(Fees); L'Oreal USA Inc. – Advisory Board(Fees); McGraw-Hill Companies – Advisory Board(Fees), Other(Other Financial Benefit); Pfizer Inc. – Advisory Board(Fees), Investigator(Grants/Research Funding); Sanofi – Advisory Board(Fees); SkinCeuticals LLC – Consultant (1099 relationship)(Fees); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); Teva Pharmaceuticals USA – Consultant (1099 relationship)(Fees); The Skin of Color Society – Board of Directors(No Compensation Received); VeraDermics Inc. – Consultant (1099 relationship)(Fees); VisualDx – Consultant(Stock Options);
Pearl E. Grimes, MD, FAAD
AbbVie – Consultant(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); L'Oreal USA Inc. – Consultant(Grants/Research Funding); Laseroptek USA – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Investigator(Grants/Research Funding); Procter & Gamble Company – Consultant(Honoraria); Scientis – Consultant (1099 relationship)(Honoraria); SkinBetter Science – Investigator(Grants/Research Funding); Versicolor Technologies – Consultant (1099 relationship)(Honoraria), Stockholder Private Company(Honoraria);
Omar Ibrahimi, MD, PhD, FAAD
Accure, Inc – Advisory Board(No Compensation Received); Allergan, Inc – Advisory Board(Honoraria); AVAVA, LLC – Investigator(Grants/Research Funding); Cynosure-Lutronic – Consultant (1099 relationship)(Honoraria); Cytrellis Biosystems, Inc – Advisory Board(Honoraria); Quthero, Inc – Consultant (1099 relationship)(Honoraria); Unilever – Stockholder(Stock);
Carlos G Wambier, MD, IFAAD
Allergan, Inc. – Advisory Board(Fees); Applied Biology – Advisory Board(Fees); ChemistryRx – Consultant(Honoraria); Concert Pharmaceuticals – Investigator(Grants/Research Funding); Cynosure – Speaker/Faculty Education(Fees); Daniel Alain – Advisory Board(Fees); Eli Lilly – Investigator(Grants/Research Funding); Galderma Brasil Ltda – Speaker(Fees); Incyte – Advisory Board(Fees); Pfizer Inc. – Investigator(Grants/Research Funding), Speaker(Fees); Sun Pharmaceutical Industries Ltd. – Investigator(Grants/Research Funding); UCB – Investigator(Grants/Research Funding); Wambier Dermatologics, LLC – Founder(Other Financial Benefit); Young Pharmaceuticals – Advisory Board(Patent royalties or other compensation for Intellectual Property Rights);