F066 So Many Biologics, So Little Time: How to Pick Your Poison in an Era of Biologic Overload
DESCRIPTION
The biologic age has now fully encompassed dermatology with medicines available in numerous inflammatory skin diseases to provide the promise of efficacious, targeted treatments that are aligned to specific pathologic immune-mediated pathways. With 12 biologics in psoriasis, the advent of biosimilars, and numerous agents available or in late-stage development in other conditions such as atopic dermatitis, hidradenitis suppurativa, and vitiligo, this session will seek to clarify the place that biologics occupy in our treatment armamentariums for inflammatory skin conditions. Highlights will include challenging patient phenotypes and how to address them, and how to pick the ideal biologic for your patient.
LEARNING OBJECTIVES
Discuss the role of biologics in rationally targeting and treating inflammatory skin diseases, identifying optimal mechanisms in each clinical indication
Assess patient comorbidities, history, and treatment preferences to formulate treatment strategies with biologics
Develop therapeutic plans to treat challenging patients, such as those who have failed other therapies or have recalcitrant skin diseases
SCHEDULE
3:30 PM
"Why use Biologics and Biosimilars?" and Biologics for HS
George Han, MD, PhD, FAAD
3:45 PM
Biologics on the horizon for vitiligo
John Harris, MD, PhD, FAAD
4:00 PM
Considering Comorbidities in Psoriasis Patients
April W. Armstrong, MD, MPH, FAAD
4:15 PM
Putting Together Appropriate Therapeutic Ladders When Treating Psoriasis
Kenneth B. Gordon, MD, FAAD
4:30 PM
Integrating PsA into Your Psoriasis Discussion and Treatment Selection
Kristina Patrice Callis-Duffin, MD, FAAD
4:45 PM
Approaching the Challenging Psoriasis Patient
Bruce Elliot Strober, MD, PhD, FAAD
5:00 PM
Which biologic or no biologic? What would YOU do?
Sylvia Hsu, MD, FAAD
5:15 PM
Biologics for AD
Vivian Shi, MD, FAAD
DIRECTOR
George Han, MD, PhD, FAAD
SPEAKERS
April W. Armstrong, MD, MPH, FAAD
Kristina Patrice Callis-Duffin, MD, FAAD
Kenneth B. Gordon, MD, FAAD
John Harris, MD, PhD, FAAD
Sylvia Hsu, MD, FAAD
Vivian Shi, MD, FAAD
Bruce Elliot Strober, MD, PhD, FAAD
HANDOUTS
DISCLOSURES
April W. Armstrong, MD, MPH, FAAD
AbbVie – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Amgen – Advisory Board(Honoraria); Arcutis Biotherapeutics – Consultant(Honoraria); Boehringer Ingelheim – Data Safety Monitoring Board(Honoraria); Bristol-Myers Squibb – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Dermavant Sciences, Inc. – Consultant(Honoraria); Dermsquared – Advisory Board(Honoraria); Eli Lilly and Company – Advisory Board(Honoraria); Galderma USA – Advisory Board(Honoraria); Incyte – Consultant (1099 relationship)(Honoraria); Janssen Biotech – Consultant (1099 relationship)(Honoraria); Leo Pharma Inc – Consultant(Honoraria); Novartis – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Ortho Dermatologics – Speaker(Honoraria); Pfizer Inc. – Advisory Board(Honoraria); Regeneron – Advisory Board(Honoraria); Sanofi Genzyme – Consultant(Honoraria); Sun Pharmaceutical Industries Ltd. – Advisory Board(Honoraria); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); UCB – Advisory Board(Honoraria);
Kristina Patrice Callis-Duffin, MD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria), Stockholder Public Company(No Compensation Received); Alumis – Investigator(Grants/Research Funding); Amgen – Advisory Board(Honoraria), Consultant(Honoraria); Boehringer Ingelheim – Advisory Board(Honoraria), Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Celgene Corporation – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Eli Lilly and Company – Consultant(Honoraria), Investigator(Grants/Research Funding); FIDE – Consultant (1099 relationship)(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Novartis – Consultant(Honoraria), Investigator(Grants/Research Funding); Oruka Therapeutics – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); UCB – Stockholder Public Company(No Compensation Received);
Kenneth B. Gordon, MD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding); Almirall – Consultant(Honoraria); Amgen – Consultant(Honoraria); Arcutis, Inc. – Consultant(Honoraria); Boehringer Ingelheim – Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Consultant(Honoraria); Dermavant Sciences – Consultant(Honoraria); Eli Lilly and Company – Investigator(Grants/Research Funding); Incyte Corporation – Consultant(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Leo Pharma Inc – Consultant(Honoraria); Lilly ICOS LLC – Advisory Board(Honoraria), Consultant (1099 relationship)(Honoraria); Novartis Pharmaceuticals Corp. – Advisory Board(Honoraria); Othro Dermatologics – Consultant(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Consultant (1099 relationship)(Honoraria); Protagonist Therapeutics – Consultant (1099 relationship)(Honoraria); Sanofi Genzyme – Consultant(Honoraria); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); UCB – Consultant(Honoraria);
George Han, MD, PhD, FAAD
Aclaris Therapeutics, Inc. – Advisory Board(Honoraria); Alumis – Investigator(Grants/Research Funding); Avillion – Investigator(Grants/Research Funding); Boehringer Ingelheim – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Advisory Board(Honoraria); Eli Lilly and Company – Advisory Board(Honoraria), Investigator(Grants/Research Funding); First Tracks Biotherapeutics – Advisory Board(Honoraria); Incyte – Investigator(Grants/Research Funding); Incyte Corporation – Advisory Board(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); LearnHealth/LearnSkin – Speaker/Faculty Education(Honoraria); Leo Pharma – Advisory Board(Honoraria); Novartis Pharmaceuticals Corp. – Investigator(Grants/Research Funding); Ortho Dermatologics – Advisory Board(Honoraria); Pfizer Inc. – Speaker(Honoraria); Regeneron Pharmaceuticals, Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Sanofi – Advisory Board(Honoraria); Sanofi Genzyme – Speaker(Honoraria); Sun Pharmaceutical Industries Ltd. – Speaker(Honoraria); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); UCB – Advisory Board(Honoraria), Speaker(Honoraria);
John Harris, MD, PhD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding); Aclaris Therapeutics Inc. – Investigator(Grants/Research Funding); Aclaris Therapeutics, Inc. – Consultant(Fees); Aldena Therapeutics – Consultant(Fees), Founder(Stock); Almirall – Consultant(Fees); Alys Pharmaceuticals – Founder(Salary), Stockholder Private Company(Fees); Bain Capital – Consultant (1099 relationship)(Fees); Barinthus Biotherapeutics North America, Inc. – Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant (1099 relationship)(Fees); Boxer Capital Management, LLC – Consultant (1099 relationship)(Fees); Cour Pharmaceuticals – Investigator(Grants/Research Funding); Dren Bio – Investigator(Grants/Research Funding); Granular Therapeutics – Consultant(Fees); Incyte Corporation – Investigator(Grants/Research Funding); Klirna Biotech, Inc. – Founder(Stock); Klirna Therapeutics – Founder(Stock); Leo Pharma Inc – Investigator(Grants/Research Funding); NexImmune – Investigator(Grants/Research Funding); Nira Biosciences, Inc. – Consultant(Fees), Founder(Stock); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Villaris Therapeutics, Inc – Founder(Stock), Investigator(Grants/Research Funding); Vimela – Consultant(Honoraria), Stockholder(Stock); Vividion Therapeutics – Consultant (1099 relationship)(Fees);
Sylvia Hsu, MD, FAAD
argenx – Investigator(Grants/Research Funding); CoreEvitas, LLC – Investigator(Grants/Research Funding); Galderma – Advisory Board(Honoraria); OncLive State of the Science Summit – Advisory Board(Honoraria);
Vivian Shi, MD, FAAD
AbbVie – Advisory Board(Fees), Speaker(Fees); Alumis – Advisory Board(Honoraria); Aristea Therapeutics – Advisory Board(Fees); Bain Capital – Consultant (1099 relationship)(Fees); Boehringer Ingelheim – Advisory Board(Fees); Burt's Bees – Consultant(Fees); Ceraclere – Consultant (1099 relationship)(Fees); Dematology Foundation – Other(Grants/Research Funding); Demira – Advisory Board(Fees); Dermavant Sciences, Inc. – Advisory Board(Fees); Eli Lilly and Company – Advisory Board(Fees); Foundation of Atopic Dermatitis – Other(Grants/Research Funding); Galderma – Advisory Board(Fees); Genentech, Inc. – Advisory Board(Honoraria); Global Parents for Eczema Research – Consultant(No Compensation Received); GpSkin – Consultant(Fees); HS Foundation – Board of Directors(No Compensation Received); Incyte – Advisory Board(Honoraria); Incyte Corporation – Advisory Board(Honoraria); LearnHealth/LearnSkin – Other(Fees), Stockholder(Stock); Leo Pharma – Consultant (1099 relationship)(Fees); Menlo Therapeutics – Advisory Board(Fees); National Eczema Association – Consultant (1099 relationship)(Honoraria), Speaker(No Compensation Received); Novartis – Advisory Board(Fees); Pfizer Inc. – Advisory Board(Fees); Polyfins, Inc – Consultant (1099 relationship)(Fees); Regeneron – Speaker(Fees); Sanofi Genzyme – Advisory Board(Fees), Speaker(Fees); Skin Actives Scientific – Other(Grants/Research Funding); Sun Pharmaceutical Industries Ltd. – Advisory Board(Fees); UCB Pharma – Advisory Board(Honoraria);
Bruce Elliot Strober, MD, PhD, FAAD
AbbVie – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); Alumis – Consultant(Fees); Amgen – Consultant (1099 relationship)(Fees); Arcutis, Inc. – Consultant(Fees), Speaker(Honoraria); Boehringer Ingelheim – Consultant(Honoraria); Bristol Myers Squibb – Speaker(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Connect Biopharma LLC – Stockholder(Other Financial Benefit); CoreEvitas, LLC – Advisory Board(Honoraria), Investigator(Fees); Eli Lilly and Company – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); Johnson and Johnson – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees), Speaker(Honoraria); Leo Pharma Inc – Advisory Board(Honoraria), Consultant(Honoraria); Meiji Seika Pharma Co., Ltd – Consultant(Fees); Mindera – Stockholder(Other Financial Benefit); Novartis Pharmaceuticals Corp. – Advisory Board(Honoraria), Consultant(Honoraria); Oruka Therapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria); Sanofi/Regeneron – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); UCB – Advisory Board(Honoraria), Consultant(Fees), Speaker(Honoraria);